apoptosome:细胞死亡的心脏和灵魂的机器。

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apoptosome:细胞死亡的心脏和灵魂的机器。

瘤。1999年4月,1 (1):5 - 15。

PubMed ID

10935465 (在PubMed

]

文摘

细胞凋亡是一个基本的生物过程编排自己的self-demise后生动物细胞。C基因分析的线虫线虫鉴定自杀的三个核心组件装置包括CED-3、CED-4, CED-9。一组类似的核心成分存在于哺乳动物细胞,包括caspase-9、Apaf-1,分别和bcl - 2 / xL。CED-3 CED-4,连同他们的哺乳动物相比,函数来杀死细胞,而哺乳动物CED-9及其等价物保护细胞免受死亡。这些核心组件在三元混合复杂生化反应最近被称为“apoptosome。”The C elegans protein EGL-1 and its mammalian counterparts, pro-apoptotic members of the bcl-2 family, induce cell death by disrupting apoptosome interactions. Thus, EGL-1 may represent a primordial signal integrator for the apoptosome. Various biochemical processes including oligomerization, adenosine triphosphate ATP/dATP binding, and cytochrome c interaction play a role in regulating the ternary death complex. Recent studies suggest that cell death receptors, such as CD95, may amplify their suicide signal by activating the apoptosome. These mutual associations by core components of the suicide apparatus provide a molecular framework in which diverse death signals likely interface. Understanding the apoptosome and its cellular connections will facilitate the design of novel therapeutic strategies for cancer and other disease states in which apoptosis plays a pivotal role.

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药物靶点

药物	目标	类	生物	药理作用	行动
三磷酸腺苷	凋亡protease-activating因子1	蛋白质	人类	未知的	不可用	细节