Oligopeptide fragments of the enkephalin molecule interfere with hematopoietic cell colony formation.
Article Details
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Citation
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Breljak D, Boranic M, Horvat S
Oligopeptide fragments of the enkephalin molecule interfere with hematopoietic cell colony formation.
Int J Immunopathol Pharmacol. 2000 Jan-Apr;13(1):13-19.
- PubMed ID
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12749773 [View in PubMed]
- Abstract
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Dipeptide Tyr-Gly and tripeptide Tyr-Gly-Gly representing the NH(2)-end of the Met-enkephalin molecule inhibited the GM-colony formation in clonal cultures of mouse bone marrow cells. Intermediate or C00H-terminal dipeptides Gly-Gly and Phe-Met respectively were inneffective. The suppressive effects were not abolished by opioid receptor blocking agent naloxone and only partly so by depletion of the accessory (adherent) cells. The results are congruent with idea that neuropeptides and products of their enzymatic degradation participate in the regulation of hematopoiesis.
DrugBank Data that Cites this Article
- Drug Targets
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Drug Target Kind Organism Ph值armacological Action Actions Naloxone Delta-type opioid receptor Protein Humans YesAntagonistDetails