半胱氨酸和高凝结状态原发性胆汁性肝硬化。
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Biagini先生,Tozzi Marcucci R, Paniccia R, Fedi年代,米拉尼年代,加利,Ceni E, Capanni M,蝠鲼R Abbate R,前者Surrenti C
半胱氨酸和高凝结状态原发性胆汁性肝硬化。
世界杂志。2006年3月14日,12 (10):1607 - 12。
- PubMed ID
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16570355 (在PubMed]
- 文摘
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目的:评估高凝结状态与同型半胱氨酸(HCY)在中国人民银行及其关系和止血剂系统的各个组件。方法:我们研究了51 PBC患者(43 f / 8米;平均年龄:63 + / - -13.9岁)和102名健康受试者(86名女性/ 16人;63 + -13 /年),和评估Sonoclot全血的止血剂过程分析和pfa的血小板功能- 100设备。然后测量HCY(禁食和蛋氨酸后加载),组织因子(TF) thrombin-antithrombin复合物(乙),肺动脉栓塞(d d), thrombomodulin (TM)、叶酸、维生素B6和B12等离子体水平。C677T 5 10-methylenetetrahydrofolate还原酶(MTHFR)多态性进行了分析。结果:Sonoclot率值的患者显著(P < 0.001)高于控制。Sonoclot时间高峰值和pfa - 100关闭时间可比的病人和控制。答,特遣部队和HCY水平,禁食和post-methionine加载、明显的患者(P < 0.001)高于控制。维生素缺乏发现45/51例(88.2%)。 The prevalence of the homozygous TT677 MTHFR genotype was significantly higher in patients (31.4%) than in controls (17.5%) (P<0.05). Sonoclot RATE values correlated significantly with HCY levels and TF. CONCLUSION: In PBC, hyper-HCY is related to hypovitaminosis and genetic predisposing factors. Increased TF and HCY levels and signs of endothelial activation are associated with hypercoagulability and may have an important role in blood clotting activation.