精氨酸通过抑制内源性生长抑素分泌刺激生长激素分泌。

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阿尔巴-罗斯J，穆勒OA, Schopohl J，冯魏达K

精氨酸通过抑制内源性生长抑素分泌刺激生长激素分泌。

中华临床内分泌杂志1988年12月;67(6):1186-9。

PubMed ID

2903866 (查看PubMed

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摘要

为了确定精氨酸(Arg)是如何刺激生长激素分泌的，我们研究了它与GHRH在体内和体外的相互作用。6名正常男性在4种情况下进行研究:1)精氨酸-TRH, 30 g精氨酸加入500 mL生理盐水30min后，再注射200微克精氨酸;2) GHRH-Arg-TRH, GHRH-(1-44) 100微克静注于精氨酸输注前，随后给予200微克TRH，静注;3) GHRH试验，100微克GHRH静脉滴注;4) TRH试验，给予200微克TRH静注。每次输注前30分钟和开始后120分钟，每隔15分钟采集血液样本。将大鼠垂体前叶细胞与精氨酸(3、6、15、30和60 mg/mL)和GHRH(0.05、1、5和10 nmol/L)共孵育3 h。在该培养基中测定大鼠生长激素。Arg-TRH后，平均血清GH浓度在60分钟从0.6显著增加到23.3 +/- 7.3 (+/- SE)微克/升。TRH显著增加血清TSH和PRL(最大TSH为11.1 +/- 1.8 mU/L;最大PRL为74.6 +/- 8.4微克/L)。GHRH-Arg-TRH后，血清GH最大水平显著高于单独Arg-TRH后(72.7 +/- 13.4微克/L)，而血清TSH和PRL则增加到相应水平(TSH, 10.2 +/- 3.0 mU/L; PRL, 64.4 +/- 13.6 micrograms/L). GHRH alone increased serum GH to 44.9 +/- 9.8 micrograms/L, significantly less than when GHRH, Arg, and TRH were given. TRH alone increased serum TSH to 6.6 +/- 0.6 mU/L, significantly less than the TSH response to Arg-TRH. The PRL increase after TRH only also was lower (47.2 +/- 6.8 micrograms/L) than the PRL response after Arg-TRH. In vitro Arg had no effect on basal and GHRH-stimulated GH secretion. Our results indicate that Arg administered with GHRH led to higher serum GH levels than did a maximally stimulatory dose of GHRH or Arg alone. The serum TSH response to Arg-TRH also was greater than that to TRH alone. We conclude that the stimulatory effects of Arg are mediated by suppression of endogenous somatostatin secretion.

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精氨酸