Sodium-coupled和电致交通复合维生素b维生素slc5a8烟酸,Na /葡萄糖co-transporter基因家族的一员。

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范·E, YJ Miyauchi年代,壮族L,普拉萨德PD, Ganapathy V

Sodium-coupled和电致交通复合维生素b维生素slc5a8烟酸,Na /葡萄糖co-transporter基因家族的一员。

j . 2005 5月15日,388 (Pt 1): 309 - 16。

PubMed ID

15651982 (在PubMed

]

文摘

SMCT (sodium-coupled monocarboxylate运输车;slc5a8)是乳酸的Na +耦合运输车,丙酮酸和短链脂肪酸。SMCT类似于这些已知底物、水溶性维生素b6,烟酸也存在monocarboxylate阴离子(烟酸)在生理条件下。因此,我们评估了SMCT调解烟酸酯的吸收能力。在哺乳动物细胞,克隆老鼠SMCT (slc5a8)诱导烟酸酯的吸收。SMCT-induced吸收Na +端依赖。吸收过程的米氏常数296 + / -88 microM。Na +激活动力学表明,至少有两个Na +离子参与这个过程。测试在各种结构类似物,烟酸是最有效的衬底。烟酰胺和methylnicotinate并不认可的运输车辆。 2-pyrazine carboxylate and isonicotinate interacted with the transporter to a moderate extent. SMCT-mediated uptake of nicotinate was inhibited by lactate and pyruvate. In the Xenopus laevis oocyte expression system, SMCT-mediated nicotinate transport was electrogenic, as evident from the nicotinate-induced inward currents under voltage-clamp conditions. Substrate-induced currents in this expression system corroborated the substrate specificity determined in the mammalian cell expression system. The kinetic parameters with regard to the affinity of the transporter for nicotinate and the Hill coefficient for Na+ activation, determined by using the oocyte expression system, were also similar to those obtained from the mammalian cell expression system. We conclude that SMCT functions not only as a Na+-coupled transporter for short-chain fatty acids and lactate but also as a Na+-coupled transporter for the water-soluble vitamin nicotinic acid.

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药物转运蛋白

药物	转运体	类	生物	药理作用	行动
肌醇烟酸酯	Sodium-coupled monocarboxylate转运体1	蛋白质	人类	未知的	底物	细节
烟酸	Sodium-coupled monocarboxylate转运体1	蛋白质	人类	未知的	不可用	细节