新生大鼠肝脏l -丝氨酸脱水酶和l -丝氨酸丙酮酸转氨酶的调控。

文章的细节

引用

复制到剪贴板

斯内尔K，沃克DG

新生大鼠肝脏l -丝氨酸脱水酶和l -丝氨酸丙酮酸转氨酶的调控。

生物化学学报，1974年12月;144(3):519-31。

PubMed ID

4377655 (查看PubMed

］

摘要

1.测定了胎儿和新生儿发育过程中大鼠肝脏中l-丝氨酸脱水酶和l-丝氨酸丙酮酸转氨酶的活性。2.l-丝氨酸-丙酮酸转氨酶活性在胎儿后期开始发育，在出生时迅速增加，在哺乳期达到峰值，然后在断奶时下降到成人值。3.l-丝氨酸脱水酶的活性在产前非常低，但在出生后迅速增加到一个短暂的峰值。在断奶开始前后的第二个短暂峰值之后，活动逐渐上升到成年值。这两个峰都有相似的同工酶组成。4.胎儿肝内注射胰高血糖素或二丁基环AMP后，l-丝氨酸脱水酶和l-丝氨酸-丙酸转氨酶活性均升高。环己酰亚胺或放线菌素D抑制了这两种酶的产前诱导，而放线菌素D在出生后立即阻断了l-丝氨酸脱水酶的自然升高。 Glucose or insulin administration also blocked the perinatal increase of l-serine dehydratase. 5. After the first perinatal peak of l-serine dehydratase, activity is increased by cortisol and this is inhibited by actinomycin D. After the second postnatal peak, activity is increased by amino acids or cortisol and this is insensitive to actinomycin D inhibition. Glucose administration blocks the cortisol-stimulated increase in l-serine dehydratase and also partially lowers the second postnatal peak of activity. 6. The developmental patterns of the enzymes are discussed in relation to the pathways of gluconeogenesis from l-serine. The regulation of enzyme activity by hormonal and dietary factors is discussed with reference to the changes in stimuli that occur during neonatal development and to their possible mechanisms of action.

引用本文的药库数据

药物靶点

药物	目标	种类	生物	药理作用	行动
丝氨酸	l -丝氨酸脱水酶/ l -苏氨酸脱氨酶	蛋白质	人类	未知的	不可用	细节