NAV

Perfosfamide

This drug entry is astuband has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Perfosfamide
DrugBank Accession Number
DB12727
Background

Perfosfamide has been used in trials studying the treatment of Lymphoma, Neuroblastoma, and Multiple Myeloma and Plasma Cell Neoplasm.

Type
Small Molecule
Groups
Investigational
结构体ure
 3D
Similar Structures
Weight
Average: 293.08
Monoisotopic: 292.0146494
Chemical Formula
C7H15Cl2N2O4P
Synonyms
  • Perfosfamide

Pharmacology

Indication

Not Available

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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRsBrowse all" title="" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
Not Available

Interactions

Drug InteractionsLearn More" title="" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Chemical TaxonomyProvided byClassyfire
Description
This compound belongs to the class of organic compounds known as nitrogen mustard compounds. These are compounds having two beta-haloalkyl groups bound to a nitrogen atom.
Kingdom
Organic compounds
Super Class
Organic nitrogen compounds
Class
Organonitrogen compounds
Sub Class
Nitrogen mustard compounds
Direct Parent
Nitrogen mustard compounds
Alternative Parents
Phosphoric monoester diamides/Oxazaphosphinanes/Peroxols/Oxacyclic compounds/Azacyclic compounds/Alkyl hydroperoxides/Organochlorides/Organic oxides/Hydrocarbon derivatives/Alkyl chlorides
Substituents
Aliphatic heteromonocyclic compound/Alkyl chloride/Alkyl halide/Alkyl hydroperoxide/Azacycle/Hydrocarbon derivative/Hydroperoxide/Nitrogen mustard/Organic oxide/Organic oxygen compound
Molecular Framework
Aliphatic heteromonocyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
U880A4FUDA
CAS number
62435-42-1
InChI Key
VPAWVRUHMJVRHU-VGDKGRGNSA-N
InChI
InChI=1S/C7H15Cl2N2O4P/c8-2-4-11(5-3-9)16(13)10-7(15-12)1-6-14-16/h7,12H,1-6H2,(H,10,13)/t7-,16-/m1/s1
IUPAC Name
(2R,4R)-2-[bis(2-chloroethyl)amino]-4-hydroperoxy-1,3,2lambda5-oxazaphosphinan-2-one
SMILES
OO[C@@H]1CCO[P@](=O)(N1)N(CCCl)CCCl

References

一般引用
Not Available
PubChem Compound
9554809
PubChem Substance
347828921
ChemSpider
7832817
ChEBI
135223
ChEMBL
CHEMBL421584
ZINC
ZINC000043226442
Wikipedia
Perfosfamide

Clinical Trials

Clinical TrialsLearn More" title="" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
Phase Status Purpose Conditions Count
2 Completed Treatment Lymphoma/Multiple Myeloma and Plasma Cell Neoplasm 1
2 Completed Treatment Neuroblastoma (NB) 1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Property Value Source
Water Solubility 13.3 mg/mL ALOGPS
logP 0.19 ALOGPS
logP 0.39 Chemaxon
logS -1.3 ALOGPS
pKa (Strongest Acidic) 11.36 Chemaxon
pKa (Strongest Basic) 0.0046 Chemaxon
Physiological Charge 0 Chemaxon
Hydrogen Acceptor Count 4 Chemaxon
Hydrogen Donor Count 2 Chemaxon
Polar Surface Area 71.03 Å2 Chemaxon
Rotatable Bond Count 6 Chemaxon
Refractivity 60.44 m3·mol-1 Chemaxon
Polarizability 25.49 Å3 Chemaxon
Number of Rings 1 Chemaxon
Bioavailability 1 Chemaxon
Rule of Five Yes Chemaxon
Ghose Filter Yes Chemaxon
Veber's Rule No Chemaxon
医学博士DR-like Rule No Chemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Spectrum Spectrum Type Splash Key
Predicted GC-MS Spectrum - GC-MS Predicted GC-MS Not Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available

Drug created at October 20, 2016 23:52 / Updated at February 21, 2021 18:53