Codeine sulfate anhydrousProduct ingredient forCodeine

Show full entry for Codeine
Name
Codeine sulfate anhydrous
Drug Entry
Codeine

The relief of pain (analgesia) is a primary goal for enhancing the quality of life of patients and for increasing the ability of patients to engage in day to day activities. Codeine, an opioid analgesic, was originally approved in the US in 1950 and is a drug used to decrease pain by increasing the threshold for pain without impairing consciousness or altering other sensory functions. Opiates such as codeine are derived from the poppy plant,Papaver somniferum(Papaveraceae).4

Codeine is utilized as a central analgesic, sedative, hypnotic, antinociceptive, and antiperistaltic agent, and is also recommended in certain diseases with incessant coughing.Label,4

See full entry for Codeine
Accession Number
DBSALT000031
Structure
MOL SDF PDB SMILES InChI
Similar Structures
Synonyms
Not Available
UNII
AVW5HY4N2E
CAS Number
1420-53-7
Weight
Average: 696.81
Monoisotopic: 696.271666799
Chemical Formula
C36H44N2O10S
InChI Key
BCXHDORHMMZBBZ-DORFAMGDSA-N
InChI
InChI=1S/2C18H21NO3.H2O4S/c2*1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19;1-5(2,3)4/h2*3-6,11-13,17,20H,7-9H2,1-2H3;(H2,1,2,3,4)/t2*11-,12+,13-,17-,18-;/m00./s1
IUPAC Name
bis((1S,5R,13R,14S,17R)-10-methoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0¹,¹³.0⁵,¹⁷.0⁷,¹⁸]octadeca-7(18),8,10,15-tetraen-14-ol); sulfuric acid
SMILES
OS(O)(=O)=O.[H][C@@]12OC3=C(OC)C=CC4=C3[C@@]11CCN(C)[C@]([H])(C4)[C@]1([H])C=C[C@]2([H])O.[H][C@@]12OC3=C(OC)C=CC4=C3[C@@]11CCN(C)[C@]([H])(C4)[C@]1([H])C=C[C@]2([H])O
PubChem Compound
6098421
ChemSpider
4514337
Wikipedia
Codeine
Predicted Properties
Property Value Source
Water Solubility 0.577 mg/mL ALOGPS
logP 1.2 ALOGPS
logP 1.34 Chemaxon
logS -2.7 ALOGPS
pKa (Strongest Acidic) 13.78 Chemaxon
pKa (Strongest Basic) 9.19 Chemaxon
Physiological Charge 1 Chemaxon
Hydrogen Acceptor Count 4 Chemaxon
Hydrogen Donor Count 1 Chemaxon
Polar Surface Area 41.93 Å2 Chemaxon
Rotatable Bond Count 2 Chemaxon
Refractivity 84.6 m3·mol-1 Chemaxon
Polarizability 32.05 Å3 Chemaxon
Number of Rings 10 Chemaxon
Bioavailability 1 Chemaxon
Rule of Five No Chemaxon
Ghose Filter No Chemaxon
Veber's Rule No Chemaxon
医学博士DR-like Rule No Chemaxon