门诊老年人氟哌酸治疗和糖代谢。

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Park-Wyllie LY, Juurlink DN,科普,Shah BR, Stukel助教,Stumpo C,梳妆台L,低DE Mamdani毫米

门诊老年人氟哌酸治疗和糖代谢。

郑传经地中海J。2006年3月30日,354 (13):1352 - 61。Epub 2006 3月1。

PubMed ID

16510739 (在PubMed

]

文摘

背景:氟哌酸与低血糖和高血糖有关。我们检查了dysglycemia-related健康结果相关的各种抗生素在安大略省人口大约140万,加拿大,66岁及以上居民。方法:我们进行了两次以人群为基础的,嵌套病例对照研究。第一、病例患者的人在医院接受治疗后低血糖与大环内酯物门诊治疗,第二代头孢菌素或呼吸氟喹诺酮类(氟哌酸、左氧氟沙星、莫西沙星,环丙沙星)。第二、病例患者的人收到了医院照顾高血糖。为每一个病人,我们确定了五个控制匹配根据年龄、性别、糖尿病的存在与否,抗生素治疗的时机。结果:2002年4月至2004年3月,我们确定了788名患者治疗低血糖后30天内抗生素治疗。与大环内酯物抗生素、氟哌酸与增加低血糖的风险(调整后的优势比,4.3;95%置信区间,2.9至6.3)。左氧氟沙星也略有增加(风险调整后的优势比,1.5; 95 percent confidence interval, 1.2 to 2.0), but no such risk was seen with moxifloxacin, ciprofloxacin, or cephalosporins. We then identified 470 patients treated for hyperglycemia within 30 days after antibiotic therapy. As compared with macrolides, gatifloxacin was associated with a considerably increased risk of hyperglycemia (adjusted odds ratio, 16.7; 95 percent confidence interval, 10.4 to 26.8), but no risk was noted with the other antibiotics. Risks were similar in the two studies regardless of the presence or absence of diabetes. CONCLUSIONS: As compared with the use of other broad-spectrum oral antibiotics, including other fluoroquinolones, the use of gatifloxacin among outpatients is associated with an increased risk of in-hospital treatment for both hypoglycemia and hyperglycemia.

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药物

氟哌酸