Antipsoriatics for Topical Use

Name
Antipsoriatics for Topical Use
Accession Number
DBCAT002153
Description

Not Available

ATC Classification
Drugs
Drug Drug Description
Calcitriol An active metabolite of vitamin D that is used to treat hyperparathyroidism and is also used in dialysis patients to combat hypocalcemia.
Tazarotene An acetylenic retinoid used to treat fine wrinkles, mottled pigmentation of the skin, acne vulgaris, and plaque psoriasis.
Fumaric acid Not Available
Calcipotriol A topical synthetic vitamin D2 derivative used in the treatment of plaque psoriasis.
Anthralin An anthracene used to treat stable plaque psoriasis.
Tacalcitol A vitamin D analog indicated in the treatment of mild to moderate plaque psoriasis.
Methoxsalen A furocoumarin used to treat psoriasis and vitiligo.
Trioxsalen A psoralen derivative that has been used in combination with UV light to treat vitiligo, but has been discontinued by its manufacturer.
Ulobetasol A lipocortin corticosteroid used to treat inflammatory and pruritic corticosteroid-responsive dermatoses.
Drugs & Drug Targets
Drug Target Type
Calcitriol Vitamin D3 receptor target
Calcitriol 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial enzyme
Calcitriol Cytochrome P450 3A4 enzyme
Calcitriol Homeobox protein Hox-A10 target
Calcitriol Vitamin D-binding protein carrier
Tazarotene Retinoic acid receptor alpha target
Tazarotene Retinoic acid receptor RXR-beta target
Tazarotene Retinoic acid receptor gamma target
Tazarotene Retinoic acid receptor beta target
Tazarotene Cytochrome P450 2C8 enzyme
Fumaric acid Malate dehydrogenase target
Fumaric acid Fumarate reductase flavoprotein subunit target
Fumaric acid NAD-dependent malic enzyme, mitochondrial target
Fumaric acid Fumarylacetoacetase target
Fumaric acid Fumarate reductase flavoprotein subunit target
Calcipotriol Vitamin D3 receptor target
Calcipotriol Myeloperoxidase enzyme
Calcipotriol 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial enzyme
Anthralin Keratin, type II cytoskeletal 2 epidermal target
Anthralin C-Jun-amino-terminal kinase-interacting protein 1 target
Anthralin Keratin, type I cytoskeletal 12 target
Methoxsalen DNA target
Methoxsalen Cytochrome P450 2A6 enzyme
Methoxsalen Cytochrome P450 1A2 enzyme
Methoxsalen Cytochrome P450 1A1 enzyme
Methoxsalen Cytochrome P450 2A13 enzyme
Trioxsalen DNA target
Ulobetasol Corticosteroid-binding globulin carrier
Ulobetasol Glucocorticoid receptor target