NAV

Enprostil

This drug entry is astuband has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Enprostil
DrugBank Accession Number
DB13824
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
 3D
Similar Structures
Weight
Average: 400.471
Monoisotopic: 400.188588622
Chemical Formula
C23H28O6
Synonyms
  • Enprostil

Pharmacology

Indication

Not Available

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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

的体积分布

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRsBrowse all" title="" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
Not Available

Interactions

Drug InteractionsLearn More" title="" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction
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Aceclofenac The therapeutic efficacy of Enprostil can be decreased when used in combination with Aceclofenac.
Acemetacin The therapeutic efficacy of Enprostil can be decreased when used in combination with Acemetacin.
Acetylsalicylic acid The therapeutic efficacy of Enprostil can be decreased when used in combination with Acetylsalicylic acid.
Alclofenac The therapeutic efficacy of Enprostil can be decreased when used in combination with Alclofenac.
Aminophenazone The therapeutic efficacy of Enprostil can be decreased when used in combination with Aminophenazone.
Antipyrine The therapeutic efficacy of Enprostil can be decreased when used in combination with Antipyrine.
Antrafenine The therapeutic efficacy of Enprostil can be decreased when used in combination with Antrafenine.
Balsalazide The therapeutic efficacy of Enprostil can be decreased when used in combination with Balsalazide.
Benorilate The therapeutic efficacy of Enprostil can be decreased when used in combination with Benorilate.
Benoxaprofen The therapeutic efficacy of Enprostil can be decreased when used in combination with Benoxaprofen.
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Food Interactions
Not Available

Categories

ATC Codes
A02BB02 — Enprostil
Drug Categories
Chemical TaxonomyProvided byClassyfire
Description
This compound belongs to the class of organic compounds known as phenol ethers. These are aromatic compounds containing an ether group substituted with a benzene ring.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Phenol ethers
Sub Class
Not Available
Direct Parent
Phenol ethers
Alternative Parents
Phenoxy compounds/Fatty acid methyl esters/Alkyl aryl ethers/Cyclopentanols/Methyl esters/Cyclic ketones/Cyclic alcohols and derivatives/Monocarboxylic acids and derivatives/Organic oxides/沪元drocarbon derivatives
Substituents
Alcohol/Alkyl aryl ether/Aromatic homomonocyclic compound/Carbonyl group/Carboxylic acid derivative/Carboxylic acid ester/Cyclic alcohol/Cyclic ketone/Cyclopentanol/Ether
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
J4IP5Z9DAU
CAS number
73121-56-9
InChI Key
PTOJVMZPWPAXER-FPXSIRDUSA-N
InChI
InChI=1S/C23H28O6/c1-28-23(27)12-8-3-2-7-11-19-20(22(26)15-21(19)25)14-13-17(24)16-29-18-9-5-4-6-10-18/h3-7,9-10,13-14,17,19-20,22,24,26H,8,11-12,15-16H2,1H3/b14-13+/t2?,17-,19-,20-,22-/m0/s1
IUPAC Name
methyl 7-[(1S,2S,3S)-3-hydroxy-2-[(1E,3S)-3-hydroxy-4-phenoxybut-1-en-1-yl]-5-oxocyclopentyl]hepta-4,5-dienoate
SMILES
COC(=O)CCC=C=CC[C@H]1[C@H](\C=C\[C@H](O)COC2=CC=CC=C2)[C@@H](O)CC1=O

References

一般引用
Not Available
ChemSpider
8153928
ChEBI
31538
Wikipedia
Enprostil

Clinical Trials

Clinical TrialsLearn More" title="" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
Phase Status Purpose Conditions Count

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Property Value Source
Water Solubility 0.0149 mg/mL ALOGPS
logP 2.58 ALOGPS
logP 2.59 Chemaxon
logS -4.4 ALOGPS
pKa (Strongest Acidic) 13.99 Chemaxon
pKa (Strongest Basic) -2.9 Chemaxon
Physiological Charge 0 Chemaxon
沪元drogen Acceptor Count 5 Chemaxon
沪元drogen Donor Count 2 Chemaxon
Polar Surface Area 93.06 Å2 Chemaxon
Rotatable Bond Count 11 Chemaxon
Refractivity 111.36 m3·mol-1 Chemaxon
Polarizability 43.51 Å3 Chemaxon
Number of Rings 2 Chemaxon
Bioavailability 1 Chemaxon
Rule of Five Yes Chemaxon
Ghose Filter Yes Chemaxon
Veber's Rule No Chemaxon
医学博士DR-like Rule No Chemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Spectrum Spectrum Type Splash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available

Drug created at June 23, 2017 20:49 / Updated at February 21, 2021 18:54