P2X purinoceptor 4

Details

Name
P2X purinoceptor 4
Synonyms
  • ATP receptor
  • P2X4
  • Purinergic receptor
Gene Name
P2RX4
Organism
Humans
Amino acid sequence
>lcl|BSEQ0009820|P2X purinoceptor 4 MAGCCAALAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDSV VSSVTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPEIP DATTVCKSDASCTAGSAGTHSNGVSTGRCVAFNGSVKTCEVAAWCPVEDDTHVPQPAFLK AAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLGKIVENAG HSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYY RDLAGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVLYC MKKRLYYREKKYKYVEDYEQGLASELDQ
Number of residues
388
分子量
43368.725
Theoretical pI
Not Available
GO Classification
Functions
ATP binding/cadherin binding/copper ion binding/药物绑定/extracellular ATP-gated cation channel activity/protein homodimerization activity/purinergic nucleotide receptor activity/受体结合/zinc ion binding
Processes
apoptotic signaling pathway/calcium ion transport/cellular response to ATP/endothelial cell activation/excitatory postsynaptic potential/ion transmembrane transport/膜去极化/negative regulation of cardiac muscle hypertrophy/neuronal action potential/nitric oxide biosynthetic process/positive regulation of calcium ion transport/positive regulation of calcium ion transport into cytosol/positive regulation of calcium-mediated signaling/positive regulation of nitric oxide biosynthetic process/positive regulation of prostaglandin secretion/protein homooligomerization/purinergic nucleotide receptor signaling pathway/regulation of blood pressure/regulation of cardiac muscle contraction/regulation of sodium ion transport/relaxation of cardiac muscle/response to ATP/response to fluid shear stress/sensory perception of pain/signal transduction/tissue homeostasis/transport/vasodilation
Components
apical part of cell/cell junction/dendritic spine/extracellular exosome/integral component of nuclear inner membrane/integral component of plasma membrane/lysosomal membrane/membrane/neuronal cell body/perinuclear region of cytoplasm/plasma membrane/postsynaptic density/terminal bouton
一般Function
Zinc ion binding
Specific Function
Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin.
Pfam Domain Function
Transmembrane Regions
34-54 339-359
Cellular Location
Membrane
Gene sequence
>lcl|BSEQ0013934|P2X purinoceptor 4 (P2RX4) ATGGCGGGCTGCTGCGCCGCGCTGGCGGCCTTCCTGTTCGAGTACGACACGCCGCGCATC GTGCTCATCCGCAGCCGCAAAGTGGGGCTCATGAACCGCGCCGTGCAACTGCTCATCCTG GCCTACGTCATCGGGTGCTACCATCCCCATTTGGCAGAAGTGGAAATGGAGTCCCCTAGA AGGTGGGTGTTTGTGTGGGAAAAGGGCTACCAGGAAACTGACTCCGTGGTCAGCTCCGTT ACGACCAAGGTCAAGGGCGTGGCTGTGACCAACACTTCTAAACTTGGATTCCGGATCTGG GATGTGGCGGATTATGTGATACCAGCTCAGGAGGAAAACTCCCTCTTCGTCATGACCAAC GTGATCCTCACCATGAACCAGACACAGGGCCTGTGCCCCGAGATTCCAGATGCGACCACT GTGTGTAAATCAGATGCCAGCTGTACTGCCGGCTCTGCCGGCACCCACAGCAACGGAGTC TCAACAGGCAGGTGCGTAGCTTTCAACGGGTCTGTCAAGACGTGTGAGGTGGCGGCCTGG TGCCCGGTGGAGGATGACACACACGTGCCACAACCTGCTTTTTTAAAGGCTGCAGAAAAC TTCACTCTTTTGGTTAAGAACAACATCTGGTATCCCAAATTTAATTTCAGCAAGAGGAAT ATCCTTCCCAACATCACCACTACTTACCTCAAGTCGTGCATTTATGATGCTAAAACAGAT CCCTTCTGCCCCATATTCCGTCTTGGCAAAATAGTGGAGAACGCAGGACACAGTTTCCAG GACATGGCCGTGGAGGGAGGCATCATGGGCATCCAGGTCAACTGGGACTGCAACCTGGAC AGAGCCGCCTCCCTCTGCTTGCCCAGGTACTCCTTCCGCCGCCTCGATACACGGGACGTT GAGCACAACGTATCTCCTGGCTACAATTTCAGGTTTGCCAAGTACTACAGAGACCTGGCT GGCAACGAGCAGCGCACGCTCATCAAGGCCTATGGCATCCGCTTCGACATCATTGTGTTT GGGAAGGCAGGGAAATTTGACATCATCCCCACTATGATCAACATCGGCTCTGGCCTGGCA CTGCTAGGCATGGCGACCGTGCTGTGTGACATCATAGTCCTCTACTGCATGAAGAAAAGA CTCTACTATCGGGAGAAGAAATATAAATATGTGGAAGATTACGAGCAGGGTCTTGCTAGT GAGCTGGACCAGTGA
Chromosome Location
12
Locus
Not Available
External Identifiers
Resource Link
UniProtKB ID Q99571
UniProtKB Entry Name P2RX4_HUMAN
HGNC ID HGNC:8535
一般References
  1. Garcia-Guzman M, Soto F, Gomez-Hernandez JM, Lund PE, Stuhmer W: Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue. Mol Pharmacol. 1997 Jan;51(1):109-18. [Article]
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  3. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  4. Carpenter D, Meadows HJ, Brough S, Chapman G, Clarke C, Coldwell M, Davis R, Harrison D, Meakin J, McHale M, Rice SQ, Tomlinson WJ, Wood M, Sanger GJ: Site-specific splice variation of the human P2X4 receptor. Neurosci Lett. 1999 Oct 8;273(3):183-6. [Article]
  5. Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res. 2009 Feb;8(2):651-61. doi: 10.1021/pr8008012. [Article]

Drug Relations

Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details
DB09119 Eslicarbazepine acetate approved yes antagonist Details
DB14575 Eslicarbazepine approved yes Details
DB01069 Promethazine approved, investigational unknown inhibitor Details