Ticlopidine hydrochlorideProduct ingredient forTiclopidine
- Name
- Ticlopidine hydrochloride
- Drug Entry
-
Ticlopidine
Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who cannot take aspirin or in whom aspirin has not worked to prevent a thrombotic stroke. The FDA label includes a black-box warning of neutropenia, aplastic anemia, thrombotic thrombocytopenia purpura, and agranulocytosis, so it is necessary to monitor patients' WBC and platelets when they are taking ticlopidine.
- Accession Number
- DBSALT000179
- Structure
-
Structure for Ticlopidine hydrochloride (DBSALT000179)
- Synonyms
- Ticlopidine HCl
- UNII
- A1L4914FMF
- CAS Number
- 53885-35-1
- Weight
-
Average: 300.247
Monoisotopic: 299.030225589 - Chemical Formula
- C14H15Cl2NS
- InChI Key
- MTKNGOHFNXIVOS-UHFFFAOYSA-N
- InChI
-
InChI=1S/C14H14ClNS.ClH/c15-13-4-2-1-3-11(13)9-16-7-5-14-12(10-16)6-8-17-14;/h1-4,6,8H,5,7,9-10H2;1H
- IUPAC Name
-
5-[(2-chlorophenyl)methyl]-4H,5H,6H,7H-thieno[3,2-c]pyridine hydrochloride
- SMILES
-
Cl.ClC1=CC=CC=C1CN1CCC2=C(C1)C=CS2
- External Links
-
- PubChem Compound
- 65335
- ChemSpider
- 58817
- ChEBI
- 9589
- ChEMBL
- CHEMBL1717
- Wikipedia
- Ticlopidine
- Predicted Properties
-
Property Value Source Water Solubility 0.0219 mg/mL ALOGPS logP 4.25 ALOGPS logP 4.2 Chemaxon logS -4.1 ALOGPS pKa (Strongest Basic) 6.94 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 1 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 3.24 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 74.33 m3·mol-1 Chemaxon Polarizability 27.62 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon
