NAV

Ornidazole

This drug entry is astuband has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Ornidazoleis a nitroimidazole agent indicated in the treatment of infections such as trichomoniasis, amebiasis, and giardiasis.

Generic Name
Ornidazole
DrugBank Accession Number
DB13026
Background

Ornidazole has been used in trials studying the prevention of Elective Colorectal Surgery.

Type
Small Molecule
Groups
Investigational
Structure
 3D
Similar Structures
Weight
Average: 219.63
Monoisotopic: 219.0410689
Chemical Formula
C7H10ClN3O3
Synonyms
  • ornidazol
  • Ornidazole

Pharmacology

Indication

Not Available

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Associated Conditions
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRsBrowse all" title="" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
Not Available

Interactions

Drug InteractionsLearn More" title="" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction
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interactions in your software
Atracurium 可以增加阿曲库的治疗效果eased when used in combination with Ornidazole.
Atracurium besylate The therapeutic efficacy of Atracurium besylate can be increased when used in combination with Ornidazole.
Botulinum toxin type A The therapeutic efficacy of Botulinum toxin type A can be increased when used in combination with Ornidazole.
Cisatracurium The therapeutic efficacy of Cisatracurium can be increased when used in combination with Ornidazole.
Decamethonium The therapeutic efficacy of Decamethonium can be increased when used in combination with Ornidazole.
Doxacurium The therapeutic efficacy of Doxacurium can be increased when used in combination with Ornidazole.
Gallamine triethiodide The therapeutic efficacy of Gallamine triethiodide can be increased when used in combination with Ornidazole.
Letibotulinumtoxina The therapeutic efficacy of Letibotulinumtoxina can be increased when used in combination with Ornidazole.
Metocurine The therapeutic efficacy of Metocurine can be increased when used in combination with Ornidazole.
Metocurine iodide The therapeutic efficacy of Metocurine iodide can be increased when used in combination with Ornidazole.
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Food Interactions
Not Available

Products

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dosage, form, labeller, route of administration, and marketing period.
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Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image
ORCIPOL 500 MG/500 MG FILM TABLET, 10 ADET Ornidazole(500 mg)+Ciprofloxacin(500 mg) Tablet, film coated Oral World Medicine Ilac San. Ve Tic. a.s. 2020-08-14 2018-07-30 Turkey flag
ORCIPOL 500 MG/500 MG FILM TABLET, 14 ADET Ornidazole(500 mg)+Ciprofloxacin(500 mg) Tablet, film coated Oral World Medicine Ilac San. Ve Tic. a.s. 2020-08-14 2018-07-30 Turkey flag
ORCIPOL 500 MG/500 MG FILM TABLET, 20 ADET Ornidazole(500 mg)+Ciprofloxacin(500 mg) Tablet, film coated Oral World Medicine Ilac San. Ve Tic. a.s. 2020-08-14 2018-07-30 Turkey flag
ORCIPOL 500 MG/500 MG FILM TABLET, 28 ADET Ornidazole(500 mg)+Ciprofloxacin(500 mg) Tablet, film coated Oral World Medicine Ilac San. Ve Tic. a.s. 2020-08-14 2018-07-30 Turkey flag
ORNISASIN 500 MG/500 MG FILM TABLET, 10 ADET Ornidazole(500 mg)+Ciprofloxacin(500 mg) Tablet, film coated Oral GENVEON İLAÇ SAN. VE TİC. A.Ş. 2020-08-14 2018-07-30 Turkey flag
ORNISASIN 500 MG/500 MG FILM TABLET, 20 ADET Ornidazole(500 mg)+Ciprofloxacin(500 mg) Tablet, film coated Oral GENVEON İLAÇ SAN. VE TİC. A.Ş. 2020-08-14 2018-07-30 Turkey flag
SIPROFORTE 500 MG/ 500 MG FILM TABLET , 10 ADET Ornidazole(500 mg)+Ciprofloxacin(500 mg) Tablet, film coated Oral DR. SERTUS İLAÇ SAN. VE TİC. LTD. ŞTİ. 2020-08-14 2018-07-30 Turkey flag
SIPROFORTE 500 MG/ 500 MG FILM TABLET , 14 ADET Ornidazole(500 mg)+Ciprofloxacin(500 mg) Tablet, film coated Oral DR. SERTUS İLAÇ SAN. VE TİC. LTD. ŞTİ. 2020-08-14 2018-07-30 Turkey flag
SIPROFORTE 500 MG/ 500 MG FILM TABLET , 20 ADET Ornidazole(500 mg)+Ciprofloxacin(500 mg) Tablet, film coated Oral DR. SERTUS İLAÇ SAN. VE TİC. LTD. ŞTİ. 2020-08-14 2018-07-30 Turkey flag
SIPROFORTE 500 MG/ 500 MG FILM TABLET , 28 ADET Ornidazole(500 mg)+Ciprofloxacin(500 mg) Tablet, film coated Oral DR. SERTUS İLAÇ SAN. VE TİC. LTD. ŞTİ. 2020-08-14 2018-07-30 Turkey flag
Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image
ORNITOP 250 MG FILM TABLET, 20 ADET Ornidazole(250 mg) Tablet, film coated TOPRAK İLAÇ VE KİMYEVİ MADDELER SAN.VE TİC. A.Ş. 2020-08-14 Not applicable Turkey flag
ORNITOP 500 MG FILM TABLET, 10 ADET Ornidazole(500 mg) Tablet, film coated TOPRAK İLAÇ VE KİMYEVİ MADDELER SAN.VE TİC. A.Ş. 2020-08-14 Not applicable Turkey flag

Categories

ATC Codes
G01AF06 — Ornidazole J01RA09 — Ofloxacin and ornidazole J01XD03 — Ornidazole P01AB03 — Ornidazole J01RA05 — Levofloxacin and ornidazole J01RA15 — Cefixime and ornidazole J01RA12 — Ciprofloxacin and ornidazole
Drug Categories
Chemical TaxonomyProvided byClassyfire
Description
This compound belongs to the class of organic compounds known as nitroimidazoles. These are compounds containing an imidazole ring which bears a nitro group.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Azoles
Sub Class
Imidazoles
Direct Parent
Nitroimidazoles
Alternative Parents
1,2,5-trisubstituted imidazoles/Nitroaromatic compounds/N-substituted imidazoles/Heteroaromatic compounds/二级醇/Chlorohydrins/Propargyl-type 1,3-dipolar organic compounds/Azacyclic compounds/Organic oxoazanium compounds/Organic oxides
show 6 more
Substituents
1,2,5-trisubstituted-imidazole/Alcohol/Alkyl chloride/Alkyl halide/Allyl-type 1,3-dipolar organic compound/Aromatic heteromonocyclic compound/Azacycle/C-nitro compound/Chlorohydrin/Halohydrin
show 20 more
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
C-nitro compound, secondary alcohol, imidazoles, organochlorine compound (CHEBI:75176)
Affected organisms
Not Available

Chemical Identifiers

UNII
62XCK0G93T
CAS number
16773-42-5
InChI Key
IPWKIXLWTCNBKN-UHFFFAOYSA-N
InChI
InChI=1S/C7H10ClN3O3/c1-5-9-3-7(11(13)14)10(5)4-6(12)2-8/h3,6,12H,2,4H2,1H3
IUPAC Name
1-chloro-3-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol
SMILES
CC1=NC=C(N1CC(O)CCl)N(=O)=O

References

General References
  1. TITCK Product Information: Bitazol (ornidazole) solution for infusion [Link]
  2. TITCK Product Information: Bitazol (ornidazole) film-coated tablets [Link]
  3. TITCK Product Information: Bitazol (ornidazole) vaginal tablets [Link]
  4. TITCK Product Information: Ornisasin (ornidazole/ciprofloxacin hydrochloride) film-coated tablets [Link]
PubChem Compound
28061
PubChem Substance
347829160
ChemSpider
26102
RxNav
7701
ChEBI
75176
ChEMBL
CHEMBL1449676
Wikipedia
Ornidazole

Clinical Trials

Clinical TrialsLearn More" title="" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
Phase Status Purpose Conditions Count
3 Completed Prevention Elective Colorectal Surgery 1
3 Recruiting Prevention Rectal Cancer Surgery 1
3 Terminated Prevention Colon Cancer 1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Form Route Strength
Tablet, film coated 500 mg
Tablet, film coated 250 mg
Insert 阴道 500 mg
Injection, solution Intravenous 500 mg
Insert 阴道
Solution Intravenous 500 mg/3ml
Solution Intravenous
Solution Parenteral 500 mg/3ml
Injection, solution Intravenous 500 mg/3ml
Tablet, film coated Oral
Injection, solution Intravenous
Tablet, coated
Tablet Oral
Solution Parenteral 1000 mg
Injection Intravenous 500 mg/3ml
Tablet Oral 500 mg
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Property 价值 Source
Water Solubility 3.34 mg/mL ALOGPS
logP 0.37 ALOGPS
logP 0.26 Chemaxon
logS -1.8 ALOGPS
pKa(最强Acidic) 13.89 Chemaxon
pKa(最强Basic) 3.08 Chemaxon
Physiological Charge 0 Chemaxon
Hydrogen Acceptor Count 4 Chemaxon
Hydrogen Donor Count 1 Chemaxon
Polar Surface Area 83.87 Å2 Chemaxon
Rotatable Bond Count 4 Chemaxon
Refractivity 50.23 m3·mol-1 Chemaxon
Polarizability 19.593 Chemaxon
Number of Rings 1 Chemaxon
Bioavailability 1 Chemaxon
Rule of Five Yes Chemaxon
Ghose Filter Yes Chemaxon
Veber's Rule No Chemaxon
MDDR-like Rule No Chemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Spectrum Spectrum Type Splash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available
LC-MS/MS Spectrum - LC-ESI-qTof , Positive LC-MS/MS Not Available
MS/MS Spectrum - , positive LC-MS/MS splash10-00fr-0590000000-51e17e00bdee7b7e70f6
MS/MS Spectrum - , positive LC-MS/MS splash10-00fr-1590000000-10d4a11d06fa5ff22012
MS/MS Spectrum - , positive LC-MS/MS splash10-004i-3911000000-5b4872e026a447ba42bd

Drug created at October 21, 2016 02:10 / Updated at June 12, 2021 10:54