Identification
- Brand Names
-
Hemoban, Hemox A, Lumicain, Superdent Hemal, Topical Hemo-stat
- Generic Name
- Aluminum chloride
- DrugBank Accession Number
- DB11081
- Background
-
Aluminum chloride is a chemical compound with the chemical formula AlCl3. When contaminated with iron chloride, it often displays a yellow color compared to the white pure compound. It is used in various chemical applications as a Lewis base, with anhydrous aluminium trichloride being the most commonly used Lewis acid. It may also be found in over-the-counter as an antiperspirant or prescription products as an antihemorrhagic agent. In antiperspirant products, FDA approves the use of aluminum chloride as an active ingredient up to 15%, calculated on the hexahydrate form, in an aqueous solution nonaerosol dosage form4.
- Type
- Small Molecule
- Groups
- Approved, Investigational
- Structure
-
Structure for Aluminum chloride (DB11081)
- Weight
-
Average: 133.341
Monoisotopic: 131.888096562 - Chemical Formula
- AlCl3
- Synonyms
-
- Aluminium chloride
Pharmacology
- Indication
-
- Indicated for the control of minor hemorrhage during dental restorative procedures.
- Indicated to reduce underarm perspiration.
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with evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets. - Associated Conditions
- Contraindications & Blackbox Warnings
-
Avoid life-threatening adverse drug eventsImprove clinical decision support with information oncontraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support. - Pharmacodynamics
-
Aluminum chloride is a hemostatic and antiperspirant agent.
- Mechanism of action
-
Aluminum chloride is commonly used topical antiperspirant. It is proposed that aluminum chloride works by causing an obstruction of the distal sweat gland ducts, where the metal ions precipitate with mucopolysaccharides, damaging epithelial cells along the lumen of the duct and forming a plug that blocks sweat output3. Aluminum chloride is also an astringent that promotes hemostasis; it precipitates proteins on the superficial layer of mucosa and make it mechanically stronger1. It creates superficial and local coagulation in minor hemorrhages.
Target Actions Organism UGlutamate dehydrogenase 1, mitochondrial inactivatorHumans - Absorption
-
It is reported that about 17-30 % of aluminum chloride formed from the reaction between orally ingested aluminum hydroxide and hydrochloric acid of the stomach is absorbed5. In rabbits, administration of a single maximum safe oral dose aluminum chloride (333 mg Al/kg) resulted in aluminum absorption of 0.57 %5. Aluminum chloride may be absorbed via dermal route, with the uptake increasing in the microgram range but with an upper limit5.
- Volume of distribution
-
Following oral administration of 8.1 mg/kg of aluminum chloride, the steady‐state volume of distribution of aluminum was 38.4 ± 6.4 mL/kg2.
- Protein binding
-
Following oral administration of 8.1 mg/kg of aluminum chloride, the fraction of plasma protein binding of aluminum was approximately 98 %2.
- Metabolism
-
In the small intestine, aluminum chloride is rapidly converted to insoluble poorly absorbed basic aluminum salts, consisting of a mixture of hydrated aluminum oxide, oxyaluminum hydroxide, various basic aluminum carbonates, and aluminum soaps5.
- Route of elimination
-
Absorbed aluminum chloride is rapidly excreted by the kidneys in individuals with normal renal function5. Aluminum chloride may be absorbed dermally.
- Half-life
-
Following oral administration of 8.1 mg/kg of aluminum chloride, the half-life of aluminum was 5.29 ± 0.47 h2.
- Clearance
-
Following oral administration of 8.1 mg/kg of aluminum chloride, the clearance of aluminum was 8.87 ± 1.76 mL/(h*kg)2.
- Adverse Effects
-
Improve decision support & research outcomesWith structured adverse effects data, including:blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data. - Toxicity
-
Oral LD50 is 3470 mg/kg in rat and dermal LD50 is > 2 g/kg in rabbitMSDS. As aluminum accumulates in the brain, ataxia and seizures may be observed following ingestion of higher doses. Mental status changes, including obtundation, lethargy and confusion may be seen5. Liver damage has been reported in acute and chronic toxicity of aluminum5.
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRsBrowse all" title="" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
- Not Available
Interactions
- Drug InteractionsLearn More" title="" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
-
这些信息不应该被解释the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareCarbamazepine Aluminum chloride can cause a decrease in the absorption of Carbamazepine resulting in a reduced serum concentration and potentially a decrease in efficacy. Chenodeoxycholic acid Aluminum chloride can cause a decrease in the absorption of Chenodeoxycholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy. Cholic Acid Aluminum chloride can cause a decrease in the absorption of Cholic Acid resulting in a reduced serum concentration and potentially a decrease in efficacy. Deferasirox Aluminum chloride can cause a decrease in the absorption of Deferasirox resulting in a reduced serum concentration and potentially a decrease in efficacy. Dehydrocholic acid Aluminum chloride can cause a decrease in the absorption of Dehydrocholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy. Deoxycholic acid Aluminum chloride can cause a decrease in the absorption of Deoxycholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy. Dolutegravir The serum concentration of Dolutegravir can be decreased when it is combined with Aluminum chloride. Eltrombopag Aluminum chloride can cause a decrease in the absorption of Eltrombopag resulting in a reduced serum concentration and potentially a decrease in efficacy. Halofantrine Aluminum chloride can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy. Mephenytoin Aluminum chloride can cause a decrease in the absorption of Mephenytoin resulting in a reduced serum concentration and potentially a decrease in efficacy. 
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- No interactions found.
Products
-
Drug product information from 10+ global regionsOur datasets provide approved product information including:
dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions. - Product Ingredients
-
Ingredient UNII CAS InChI Key Aluminium chloride hexahydrate 3CYT62D3GA 7784-13-6 JGDITNMASUZKPW-UHFFFAOYSA-K - Active Moieties
-
Name Kind UNII CAS InChI Key Aluminium unknown CPD4NFA903 7429-90-5 XAGFODPZIPBFFR-UHFFFAOYSA-N Aluminum cation ionic 3XHB1D032B 22537-23-1 REDXJYDRNCIFBQ-UHFFFAOYSA-N - Brand Name Prescription Products
-
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Denti-care Hemostatic Solution Liquid 25 % Dental Amd Medicom Inc 1999-11-26 2006-08-03 Canada 
Frenna AC Solution 8.75 g/35g 牙;Oral; Topical Dharma Research, Inc. 2013-01-01 Not applicable US 
Gibson Healthcare Buffered Hemostatic Solution Solution 7500 mg/30mL Dental Benco Dental 2015-01-01 Not applicable US Gingi Aid 10% Liquid 100 mg / mL Dental Gingi Pak Labs, Division Of Belport Co., Inc. 1979-12-31 1996-09-09 Canada Gingi Aid 25% Liquid 250 mg / mL Dental Gingi Pak Labs, Division Of Belport Co., Inc. 1979-12-31 2004-08-16 Canada Gingi Aid Dark Braid #3 Packing 1 mg / 2.54 cm Dental Gingi Pak Labs, Division Of Belport Co., Inc. 1981-12-31 1997-08-11 Canada Gingigel Gel 200mg/gm Gel 200 mg / g 局部 Van R Dental Products Inc. 1986-12-31 2007-07-31 Canada Hemal Solution 250 mg/1g Dental Darby Dental Supply Llc 1963-02-19 Not applicable US Hemoban Solution 250 mg/1g Dental Dentsply LLC, Professional Division Trading as "Sultan Healthcare" 1963-02-19 Not applicable US Hemoban Solution 250 mg/1g Dental DSHealthcare 1963-02-19 2010-02-04 US - Over the Counter Products
-
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Aarica Liquid 15 g/100mL 局部 The Podiatree Company 2014-05-06 Not applicable US Aarica Liquid 15 g/100mL 局部 The Podiatree Company 2014-05-06 Not applicable US Antiperspirant Towlette Cloth 14 g/100g 局部 Zero Sweat 2019-06-01 Not applicable US Aquastop Liq Liquid 20 % 局部 Aqua Pharmaceuticals 1977-12-31 2002-08-15 Canada Certain Dri Roll-ON Liquid 0.12 mg/1.0mL 局部 Denison Pharmaceuticals, Llc. 2017-01-01 Not applicable US CERTAIN DRI Roll-On Liquid 12 mg/100mL 局部 DSE Healthcare Solutions, LLC 2012-05-22 2014-10-14 US Certain Dri Roll-ON Liquid 0.12 mg/1.0mL 局部 Clarion Brands, Llc 2015-11-01 Not applicable US CERTAIN DRI Roll-On Liquid 12 mg/1mL 局部 DSE Healthcare Solutions, LLC 2014-01-01 2014-10-14 US Clinical Strength MiracleDry Antiperspirant Deodorant PM Liquid 12 mg/1mL 局部 Highland Consumer Products 2012-10-15 Not applicable US Dr Sweat Liquid 15 g/100g 局部 Conopco Inc. d/b/a/ Unilever 2019-03-29 Not applicable US - Mixture Products
-
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Anti-perspirant Roll-ON Deod Aluminum chloride(2 %)+Aluminum chlorohydrate(20 %) Liquid 局部 Estee Lauder Dist 1987-12-31 2002-07-31 Canada Arrid Cream Aluminum chloride(1 %)+Aluminum chlorohydrate(21.2 %) Cream 局部 Carter Products, Division Of Carter Wallace Ns Inc. 1939-12-31 1999-09-27 Canada Lexxel Ids Aluminum chloride(23 %)+Hexamidine diisethionate(0.1 %) Gel 局部 Vivier Canada Incorporated Not applicable Not applicable Canada Mitchum Anti Perspirant Crm Scented Aluminum chloride(4 g / 100 g)+Alcloxa(250 mg / 100 g)+Aluminum chlorohydrate(19 g / 100 g) Cream 局部 Mitchum Thayer Ltd. 1965-12-31 1996-09-09 Canada Mitchum Antipersp Crm Unscented Aluminum chloride(4 %)+Alcloxa(.25 %)+Aluminum chlorohydrate(19 %) Cream 局部 Mitchum Thayer Ltd. 1978-12-31 1996-09-09 Canada Racestyptine Cord Aluminum chloride(60 mg / 100 cm)+Lidocaine(35 mg / 100 cm)+Oxyquinoline sulfate(.24 mg / 100 cm) Packing Dental Septodont 1981-12-31 2000-08-03 Canada Racestyptine Sol Aluminum chloride(25 g / 100 mL)+Oxyquinoline sulfate(100 mg / 100 mL) Liquid Dental Septodont 1977-12-31 2017-07-07 Canada Sulpak II Aluminum chloride(25 %)+Oxyquinoline sulfate(.1 %) Liquid Dental North Pacific Dental Inc. 1983-12-31 1997-12-22 Canada Youth Dew Roll On Antipersp Deod Lot Aluminum chloride(2 %)+Aluminum chlorohydrate(20 %) Lotion 局部 Estee Lauder Dist 1986-12-31 2000-07-25 Canada - Unapproved/Other Products
-
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Frenna AC Aluminium chloride hexahydrate(8.75 g/35g) Solution 牙;Oral; Topical Dharma Research, Inc. 2013-01-01 Not applicable US Gibson Healthcare Buffered Hemostatic Solution Aluminium chloride hexahydrate(7500 mg/30mL) Solution Dental Benco Dental 2015-01-01 Not applicable US Hemal Aluminum chloride(250 mg/1g) Solution Dental Darby Dental Supply Llc 1963-02-19 Not applicable US Hemoban Aluminum chloride(250 mg/1g) Solution Dental Dentsply LLC, Professional Division Trading as "Sultan Healthcare" 1963-02-19 Not applicable US Hemoban Aluminum chloride(250 mg/1g) Solution Dental DSHealthcare 1963-02-19 2010-02-04 US Hemostat Aluminium chloride hexahydrate(7500 mg/30mL) Solution Dental Pearson Dental Supplies INC. 2013-01-15 Not applicable US Hemostat Aluminium chloride hexahydrate(7500 mg/30mL) Solution Dental Cargus International, Inc. 2013-03-01 Not applicable US Hemostatic Solution Aluminium chloride hexahydrate(7500 mg/30mL) Solution Dental Crosstex International Inc. 2013-01-15 2016-04-08 US Hemox A Aluminium chloride hexahydrate(7500 mg/30mL) Solution Dental Mycone Dental Supply Co., Inc Dba Keystone Industries And Deepak Products Inc. 2013-01-15 Not applicable US Hypercare Aluminium chloride hexahydrate(1 g/5mL)+Ethanol(3.75 g/5mL) Solution 局部 Stratus Pharmaceuticals 2008-04-21 2015-04-09 US
Categories
- ATC Codes
- D10AX01 — Aluminium chloride
- Drug Categories
- Chemical TaxonomyProvided byClassyfire
-
- Description
- This compound belongs to the class of inorganic compounds known as post-transition metal chlorides. These are inorganic compounds in which the largest halogen atom is Chlorine, and the heaviest metal atom is a post-transition metal.
- Kingdom
- Inorganic compounds
- Super Class
- Mixed metal/non-metal compounds
- Class
- Post-transition metal salts
- Sub Class
- Post-transition metal chlorides
- Direct Parent
- Post-transition metal chlorides
- Alternative Parents
- Inorganic chloride salts
- Substituents
- Inorganic chloride salt/Inorganic salt/Post-transition metal chloride
- Molecular Framework
- Not Available
- External Descriptors
- aluminium coordination entity (CHEBI:30114)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- LIF1N9568Y
- CAS number
- 7446-70-0
- InChI Key
- VSCWAEJMTAWNJL-UHFFFAOYSA-K
- InChI
-
InChI=1S/Al.3ClH/h;3*1H/q+3;;;/p-3
- IUPAC Name
-
trichloroalumane
- SMILES
-
Cl[Al](Cl)Cl
References
- General References
-
- Tarighi P, Khoroushi M: A review on common chemical hemostatic agents in restorative dentistry. Dent Res J (Isfahan). 2014 Jul;11(4):423-8. [Article]
- Gupta S, Waters D, Gwilt P: Absorption and disposition of aluminum in the rat Journal of Pharmaceutical Sciences. 1986 June 1;75(6):586-589. [Article]
- Khademi Kalantari K, Zeinalzade A, Kobarfard F, Nazary Moghadam S: The effect and persistency of 1% aluminum chloride hexahydrate iontophoresis in the treatment of primary palmar hyperhidrosis. Iran J Pharm Res. 2011 Summer;10(3):641-5. [Article]
- FDA CFR - Code of Federal Regulations Title 21, PART 350: ANTIPERSPIRANT DRUG PRODUCTS FOR OVER-THE-COUNTER HUMAN USE [Link]
- ALUMINUM CHLORIDE - National Library of Medicine HSDB ... - Toxnet [Link]
- TITCK Product Information: Anti-Fosfat AL (aluminum chloride complex) oral capsule [Link]
- External Links
-
- PubChem Compound
- 24012
- PubChem Substance
- 347827889
- ChemSpider
- 22445
- 46241
- ChEBI
- 30114
- ChEMBL
- CHEMBL3833401
- Wikipedia
- Aluminium_chloride
- MSDS
-
Download (50.7 KB)
Clinical Trials
- Clinical TrialsLearn More" title="" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
-
Phase Status Purpose Conditions Count 1 Completed Treatment Hyperhidrosis 1
Pharmacoeconomics
- Manufacturers
-
Not Available
- 外包商
-
Not Available
- Dosage Forms
-
Form Route Strength Liquid 局部 15 g/100mL Capsule Oral 300 mg Liquid 局部 Cloth 局部 14 g/100g Liquid 局部 20 % Liquid 局部 0.12 mg/1.0mL Liquid 局部 12 mg/100mL Liquid 局部 12 mg/1mL Liquid Dental 25 % Liquid 局部 15 g/100g Gel 局部 150 mg/1mL Solution 牙;Oral; Topical 8.75 g/35g Solution Dental 7500 mg/30mL Liquid Dental 100 mg / mL Liquid Dental 250 mg / mL Packing 牙;局部 1 mg / 2.54 cm Packing Dental 1 mg / 2.54 cm Solution 牙;Oral; Periodontal 3.75 g/15mL Gel 局部 200 mg / g Cream 局部 15 g/100mL Liquid Dental 250 mg / g Gel 局部 15 g/100mL Solution 局部 Solution 局部 15 g/100mL Gel 局部 Solution 局部 250 mg/1g Cream 局部 Aerosol, spray 局部 150 mg/1mL Liquid 局部 150 mg/1mL Packing Dental Solution 局部 250 mg/1ml Solution 牙;Oral; Topical 7500 mg/30mL Liquid Dental Solution 局部 140毫克/毫升 Solution 局部 150 mg/1mL Solution Dental 250 mg/1g Stick 局部 250 mg/1g Liquid 局部 0.0625 g/1g Spray Epidural 4.4375 g/35.5mL Spray Epidural 5.325 g/35.5mL Lotion 局部 Liquid 局部 0.15 g/1g Liquid 局部 15 mg/1mL Liquid 局部 0.12 g/1g - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
-
Property Value Source melting point (°C) 194 MSDS water solubility Water reactive MSDS - Predicted Properties
-
Property Value Source Water Solubility 3.63 mg/mL ALOGPS logP 2.23 ALOGPS logP 1.65 Chemaxon logS -1.6 ALOGPS Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 0 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 0 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 18.41 m3·mol-1 Chemaxon Polarizability 9.49 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
-
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available
Targets
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- Kind
- Protein
- Organism
- Humans
- Pharmacological action
-
Unknown
- Actions
-
Inactivator
- General Function
- Nad+ binding
- Specific Function
- 线粒体谷氨酸dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in th...
- Gene Name
- GLUD1
- Uniprot ID
- P00367
- Uniprot Name
- Glutamate dehydrogenase 1, mitochondrial
- 分子量
- 61397.315 Da
References
- Yang SJ, Huh JW, Lee JE, Choi SY, Kim TU, Cho SW: Inactivation of human glutamate dehydrogenase by aluminum. Cell Mol Life Sci. 2003 Nov;60(11):2538-46. [Article]
Drug created at December 03, 2015 16:51 / Updated at April 26, 2023 07:53