NAV

Norgestrienone

This drug entry is astuband has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Norgestrienone
DrugBank Accession Number
DB13563
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
 3D
Similar Structures
Weight
Average: 294.394
Monoisotopic: 294.161979948
Chemical Formula
C20H22O2
Synonyms
  • Norgestrienone

Pharmacology

Indication

Not Available

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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

的体积分布

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRsBrowse all" title="" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
Not Available

Interactions

Drug InteractionsLearn More" title="" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction
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Abciximab The risk or severity of adverse effects can be increased when Norgestrienone is combined with Abciximab.
Acenocoumarol The risk or severity of adverse effects can be increased when Norgestrienone is combined with Acenocoumarol.
Acetaminophen The metabolism of Norgestrienone can be increased when combined with Acetaminophen.
Acetazolamide The metabolism of Norgestrienone can be increased when combined with Acetazolamide.
Acetohexamide The therapeutic efficacy of Acetohexamide can be decreased when used in combination with Norgestrienone.
Acitretin The therapeutic efficacy of Norgestrienone can be decreased when used in combination with Acitretin.
Alitretinoin The therapeutic efficacy of Norgestrienone can be decreased when used in combination with Alitretinoin.
Alpelisib The metabolism of Norgestrienone can be increased when combined with Alpelisib.
Alteplase The risk or severity of adverse effects can be increased when Norgestrienone is combined with Alteplase.
Aminoglutethimide The metabolism of Norgestrienone can be increased when combined with Aminoglutethimide.
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Food Interactions
Not Available

Categories

ATC Codes
G03AC07 — Norgestrienone
Drug Categories
Chemical TaxonomyProvided byClassyfire
Description
This compound belongs to the class of organic compounds known as estrogens and derivatives. These are steroids with a structure containing a 3-hydroxylated estrane.
Kingdom
Organic compounds
Super Class
Lipids and lipid-like molecules
Class
Steroids and steroid derivatives
Sub Class
Estrane steroids
Direct Parent
Estrogens and derivatives
Alternative Parents
3-oxosteroids/17-hydroxysteroids/Cyclohexenones/Ynones/Tertiary alcohols/Cyclic alcohols and derivatives/Acetylides/Organic oxides/沪元drocarbon derivatives
Substituents
17-hydroxysteroid/3-oxosteroid/Acetylide/Alcohol/Aliphatic homopolycyclic compound/Carbonyl group/Cyclic alcohol/Cyclic ketone/Cyclohexenone/Estrogen-skeleton
Molecular Framework
Aliphatic homopolycyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
89386PYU9O
CAS number
848-21-5
InChI Key
GVDMJXQHPUYPHP-FYQPLNBISA-N
InChI
InChI=1S/C20H22O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,8,10,12,17-18,22H,4-7,9,11H2,2H3/t17-,18+,19+,20+/m1/s1
IUPAC Name
(1R,3aS,3bS,11aS)-1-ethynyl-1-hydroxy-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,11aH-cyclopenta[a]phenanthren-7-one
SMILES
[H][C@@]12CC[C@@](O)(C#C)[C@@]1(C)C=CC1=C3CCC(=O)C=C3CC[C@@]21[H]

References

一般参考ences
Not Available
ChemSpider
12749
RxNav
7519
ChEBI
135231
ChEMBL
CHEMBL1908319
ZINC
ZINC000004217177
Wikipedia
Norgestrienone

Clinical Trials

Clinical TrialsLearn More" title="" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
Phase Status Purpose Conditions Count

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Property Value Source
Water Solubility 0.0113 mg/mL ALOGPS
logP 2.97 ALOGPS
logP 2.41 Chemaxon
logS -4.4 ALOGPS
pKa (Strongest Acidic) 17.57 Chemaxon
pKa (Strongest Basic) -1.7 Chemaxon
Physiological Charge 0 Chemaxon
沪元drogen Acceptor Count 2 Chemaxon
沪元drogen Donor Count 1 Chemaxon
Polar Surface Area 37.3 Å2 Chemaxon
Rotatable Bond Count 0 Chemaxon
Refractivity 89.12 m3·mol-1 Chemaxon
Polarizability 33.61 Å3 Chemaxon
Number of Rings 4 Chemaxon
Bioavailability 1 Chemaxon
Rule of Five Yes Chemaxon
Ghose Filter Yes Chemaxon
Veber's Rule Yes Chemaxon
MDDR-like Rule No Chemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Spectrum Spectrum Type Splash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available

Drug created at June 23, 2017 20:44 / Updated at February 21, 2021 18:54