Bumadizone

This drug entry is astuband has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Bumadizone
DrugBank Accession Number
DB13286
Background

Bumadizone has been approved for use in Germany and Austria, it is a drug with anti-inflammatory, antipyretic, and analgesic properties, and was marketed for the treatment of both rheumatoid arthritis and gout1. Its use is restricted to these conditions, due to risks this drug poses1.

Type
Small Molecule
Groups
Approved
Structure
Weight
Average: 326.396
Monoisotopic: 326.163042576
Chemical Formula
C19H22N2O3
Synonyms
  • bumadizona
  • Bumadizone

Pharmacology

Indication

Not Available

Reduce drug development failure rates
Build, train, & validate machine-learning models
with evidence-based and structured datasets.
See how
Build, train, & validate predictive machine-learning models with structured datasets.
See how
Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug events
Improve clinical decision support with information oncontraindications & blackbox warnings, population restrictions, harmful risks, & more.
Learn more
Avoid life-threatening adverse drug events & improve clinical decision support.
Learn more
Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Improve decision support & research outcomes
With structured adverse effects data, including:blackbox warnings, adverse reactions, warning & precautions, & incidence rates.
Learn more
Improve decision support & research outcomes with our structured adverse effects data.
Learn more
Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRsBrowse all" title="" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
Not Available

Interactions

Drug InteractionsLearn More" title="" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction
Abacavir Bumadizone may decrease the excretion rate of Abacavir which could result in a higher serum level.
Abciximab The risk or severity of bleeding and hemorrhage can be increased when Bumadizone is combined with Abciximab.
Acebutolol Bumadizone may decrease the antihypertensive activities of Acebutolol.
Aceclofenac The risk or severity of adverse effects can be increased when Aceclofenac is combined with Bumadizone.
Acemetacin The risk or severity of adverse effects can be increased when Bumadizone is combined with Acemetacin.
Acenocoumarol The risk or severity of bleeding and hemorrhage can be increased when Bumadizone is combined with Acenocoumarol.
Acetaminophen The risk or severity of adverse effects can be increased when Acetaminophen is combined with Bumadizone.
Acetohexamide The protein binding of Acetohexamide can be decreased when combined with Bumadizone.
Acetylsalicylic acid The risk or severity of adverse effects can be increased when Acetylsalicylic acid is combined with Bumadizone.
Aclidinium Bumadizone may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Identify potential medication risks
Easily compare up to 40 drugs with our drug interaction checker.
Get severity rating, description, and management advice.
Learn more
Food Interactions
Not Available

Categories

ATC Codes
M01AB07 — Bumadizone
Drug Categories
Chemical TaxonomyProvided byClassyfire
Description
This compound belongs to the class of organic compounds known as anilides. These are organic heterocyclic compounds derived from oxoacids RkE(=O)l(OH)m (l not 0) by replacing an OH group by the NHPh group or derivative formed by ring substitution.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Anilides
Direct Parent
Anilides
Alternative Parents
Phenylhydrazines/Medium-chain fatty acids/Branched fatty acids/Amino fatty acids/1,3-dicarbonyl compounds/Carboxylic acid hydrazides/Monocarboxylic acids and derivatives/Carboxylic acids/Organopnictogen compounds/Organonitrogen compounds
show 2 more
Substituents
1,3-dicarbonyl compound/Amino fatty acid/Anilide/Aromatic homomonocyclic compound/Branched fatty acid/Carbonyl group/Carboxylic acid/Carboxylic acid derivative/Carboxylic acid hydrazide/Fatty acid
show 11 more
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
carbohydrazide, monocarboxylic acid (CHEBI:76119)
Affected organisms
Not Available

Chemical Identifiers

UNII
ATD81G944M
CAS number
3583-64-0
InChI Key
FLWFHHFTIRLFPV-UHFFFAOYSA-N
InChI
InChI=1S/C19H22N2O3/c1-2-3-14-17(19(23)24)18(22)21(16-12-8-5-9-13-16)20-15-10-6-4-7-11-15/h4-13,17,20H,2-3,14H2,1H3,(H,23,24)
IUPAC Name
2-(N,N'-diphenylhydrazinecarbonyl)hexanoic acid
SMILES
CCCCC(C(O)=O)C(=O)N(NC1=CC=CC=C1)C1=CC=CC=C1

References

一般引用
  1. WHO - Consolidated list of products whoes consumption has been banned or withdrawn [Link]
ChemSpider
18080
RxNav
19847
ChEBI
76119
ChEMBL
CHEMBL2105456
Wikipedia
Bumadizone

Clinical Trials

Clinical TrialsLearn More" title="" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
Phase Status Purpose Conditions Count

Pharmacoeconomics

Manufacturers
Not Available
外包商
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Property Value Source
Water Solubility 0.0541 mg/mL ALOGPS
logP 2.95 ALOGPS
logP 4.72 Chemaxon
logS -3.8 ALOGPS
pKa (Strongest Acidic) 4.35 Chemaxon
pKa (Strongest Basic) -7 Chemaxon
Physiological Charge -1 Chemaxon
Hydrogen Acceptor Count 4 Chemaxon
Hydrogen Donor Count 2 Chemaxon
Polar Surface Area 69.64 Å2 Chemaxon
Rotatable Bond Count 8 Chemaxon
Refractivity 93.54 m3·mol-1 Chemaxon
Polarizability 35.07 Å3 Chemaxon
Number of Rings 2 Chemaxon
Bioavailability 1 Chemaxon
Rule of Five Yes Chemaxon
Ghose Filter Yes Chemaxon
Veber's Rule No Chemaxon
MDDR-like规则 No Chemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Spectrum Spectrum Type Splash Key
Predicted GC-MS Spectrum - GC-MS Predicted GC-MS Not Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available

Drug created at June 23, 2017 20:39 / Updated at February 21, 2021 18:54