Alpha-1A adrenergic receptor
Details
- Name
- Alpha-1A adrenergic receptor
- Synonyms
-
- ADRA1C
- Alpha-1A adrenoceptor
- Alpha-1A adrenoreceptor
- Alpha-1C adrenergic receptor
- Alpha-adrenergic receptor 1c
- Gene Name
- ADRA1A
- Organism
- Humans
- Amino acid sequence
-
>拼箱| BSEQ0001000 | Alpha-1A肾上腺素能受体MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT TARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
- Number of residues
- 466
- 米olecular Weight
- 51486.005
- Theoretical pI
- 9.23
- GO Classification
-
Functionsalpha1-adrenergic receptor activity/protein heterodimerization activityProcessesactivation of phospholipase C activity/adenylate cyclase-activating adrenergic receptor signaling pathway/aging/apoptotic process/calcium ion transport into cytosol/cell-cell signaling/G-protein coupled receptor signaling pathway/intracellular signal transduction/negative regulation of cell proliferation/negative regulation of Rho protein signal transduction/norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure/phospholipase C-activating G-protein coupled receptor signaling pathway/positive regulation of action potential/positive regulation of cardiac muscle contraction/positive regulation of cytosolic calcium ion concentration/positive regulation of ERK1 and ERK2 cascade/positive regulation of MAPK cascade/positive regulation of protein kinase C signaling/positive regulation of smooth muscle contraction/positive regulation of synaptic transmission, GABAergic/positive regulation of vasoconstriction/response to drug/response to hormone/signal transduction/平滑肌收缩Componentscytosol/integral component of plasma membrane/nuclear membrane/nucleus/plasma membrane
- General Function
- Protein heterodimerization activity
- Specific Function
- This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
- Pfam Domain Function
-
- 7tm_1 (PF00001)
- Transmembrane Regions
- 28-51 65-88 100-122 144-167 182-205 274-297 306-329
- Cellular Location
- Nucleus membrane
- Gene sequence
-
>lcl|BSEQ0010352|Alpha-1A adrenergic receptor (ADRA1A) ATGGTGTTTCTCTCGGGAAATGCTTCCGACAGCTCCAACTGCACCCAACCGCCGGCACCG GTGAACATTTCCAAGGCCATTCTGCTCGGGGTGATCTTGGGGGGCCTCATTCTTTTCGGG GTGCTGGGTAACATCCTAGTGATCCTCTCCGTAGCCTGTCACCGACACCTGCACTCAGTC ACGCACTACTACATCGTCAACCTGGCGGTGGCCGACCTCCTGCTCACCTCCACGGTGCTG CCCTTCTCCGCCATCTTCGAGGTCCTAGGCTACTGGGCCTTCGGCAGGGTCTTCTGCAAC ATCTGGGCGGCAGTGGATGTGCTGTGCTGCACCGCGTCCATCATGGGCCTCTGCATCATC TCCATCGACCGCTACATCGGCGTGAGCTACCCGCTGCGCTACCCAACCATCGTCACCCAG AGGAGGGGTCTCATGGCTCTGCTCTGCGTCTGGGCACTCTCCCTGGTCATATCCATTGGA CCCCTGTTCGGCTGGAGGCAGCCGGCCCCCGAGGACGAGACCATCTGCCAGATCAACGAG GAGCCGGGCTACGTGCTCTTCTCAGCGCTGGGCTCCTTCTACCTGCCTCTGGCCATCATC CTGGTCATGTACTGCCGCGTCTACGTGGTGGCCAAGAGGGAGAGCCGGGGCCTCAAGTCT GGCCTCAAGACCGACAAGTCGGACTCGGAGCAAGTGACGCTCCGCATCCATCGGAAAAAC GCCCCGGCAGGAGGCAGCGGGATGGCCAGCGCCAAGACCAAGACGCACTTCTCAGTGAGG CTCCTCAAGTTCTCCCGGGAGAAGAAAGCGGCCAAAACGCTGGGCATCGTGGTCGGCTGC TTCGTCCTCTGCTGGCTGCCTTTTTTCTTAGTCATGCCCATTGGGTCTTTCTTCCCTGAT TTCAAGCCCTCTGAAACAGTTTTTAAAATAGTATTTTGGCTCGGATATCTAAACAGCTGC ATCAACCCCATCATATACCCATGCTCCAGCCAAGAGTTCAAAAAGGCCTTTCAGAATGTC TTGAGAATCCAGTGTCTCTGCAGAAAGCAGTCTTCCAAACATGCCCTGGGCTACACCCTG CACCCGCCCAGCCAGGCCGTGGAAGGGCAACACAAGGACATGGTGCGCATCCCCGTGGGA TCAAGAGAGACCTTCTACAGGATCTCCAAGACGGATGGCGTTTGTGAATGGAAATTTTTC TCTTCCATGCCCCGTGGATCTGCCAGGATTACAGTGTCCAAAGACCAATCCTCCTGTACC ACAGCCCGGGTGAGAAGTAAAAGCTTTTTGCAGGTCTGCTGCTGTGTAGGGCCCTCAACC CCCAGCCTTGACAAGAACCATCAAGTTCCAACCATTAAGGTCCACACCATCTCCCTCAGT GAGAACGGGGAGGAAGTCTAG
- Chromosome Location
- 8
- Locus
- 8p21-p11.2
- External Identifiers
-
Resource Link UniProtKB ID P35348 UniProtKB Entry Name ADA1A_HUMAN GenBank Protein ID 433201 GenBank Gene ID D25235 GenAtlas ID ADRA1A HGNC ID HGNC:277 - General References
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- Hirasawa A, Horie K, Tanaka T, Takagaki K, Murai M, Yano J, Tsujimoto G: Cloning, functional expression and tissue distribution of human cDNA for the alpha 1C-adrenergic receptor. Biochem Biophys Res Commun. 1993 Sep 15;195(2):902-9. [Article]
- Weinberg DH, Trivedi P, Tan CP, Mitra S, Perkins-Barrow A, Borkowski D, Strader CD, Bayne M: Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c. Biochem Biophys Res Commun. 1994 Jun 30;201(3):1296-304. [Article]
- Forray C, Bard JA, Wetzel JM, Chiu G, Shapiro E, Tang R, Lepor H, Hartig PR, Weinshank RL, Branchek TA, et al.: The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype. Mol Pharmacol. 1994 Apr;45(4):703-8. [Article]
- Tseng-Crank J, Kost T, Goetz A, Hazum S, Roberson KM, Haizlip J, Godinot N, Robertson CN, Saussy D: The alpha 1C-adrenoceptor in human prostate: cloning, functional expression, and localization to specific prostatic cell types. Br J Pharmacol. 1995 Aug;115(8):1475-85. [Article]
- Hirasawa A, Shibata K, Horie K, Takei Y, Obika K, Tanaka T, Muramoto N, Takagaki K, Yano J, Tsujimoto G: Cloning, functional expression and tissue distribution of human alpha 1c-adrenoceptor splice variants. FEBS Lett. 1995 Apr 24;363(3):256-60. [Article]
- Schwinn DA, Johnston GI, Page SO, Mosley MJ, Wilson KH, Worman NP, Campbell S, Fidock MD, Furness LM, Parry-Smith DJ, et al.: Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues. J Pharmacol Exp Ther. 1995 Jan;272(1):134-42. [Article]
- Chang DJ, Chang TK, Yamanishi SS, Salazar FH, Kosaka AH, Khare R, Bhakta S, Jasper JR, Shieh IS, Lesnick JD, Ford AP, Daniels DV, Eglen RM, Clarke DE, Bach C, Chan HW: Molecular cloning, genomic characterization and expression of novel human alpha1A-adrenoceptor isoforms. FEBS Lett. 1998 Jan 30;422(2):279-83. [Article]
- Coge F, Guenin SP, Renouard-Try A, Rique H, Ouvry C, Fabry N, Beauverger P, Nicolas JP, Galizzi JP, Boutin JA, Canet E: Truncated isoforms inhibit [3H]prazosin binding and cellular trafficking of native human alpha1A-adrenoceptors. Biochem J. 1999 Oct 1;343 Pt 1:231-9. [Article]
- Ota T,铃木Y, Nishikawa T,大月T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Faure C, Pimoule C, Vallancien G, Langer SZ, Graham D: Identification of alpha 1-adrenoceptor subtypes present in the human prostate. Life Sci. 1994;54(21):1595-605. [Article]
- Wright CD, Chen Q, Baye NL, Huang Y, Healy CL, Kasinathan S, O'Connell TD: Nuclear alpha1-adrenergic receptors signal activated ERK localization to caveolae in adult cardiac myocytes. Circ Res. 2008 Oct 24;103(9):992-1000. doi: 10.1161/CIRCRESAHA.108.176024. Epub 2008 Sep 18. [Article]
- Wright CD, Wu SC, Dahl EF, Sazama AJ, O'Connell TD: Nuclear localization drives alpha1-adrenergic receptor oligomerization and signaling in cardiac myocytes. Cell Signal. 2012 Mar;24(3):794-802. doi: 10.1016/j.cellsig.2011.11.014. Epub 2011 Nov 18. [Article]
- Shibata K, Hirasawa A, Moriyama N, Kawabe K, Ogawa S, Tsujimoto G: Alpha 1a-adrenoceptor polymorphism: pharmacological characterization and association with benign prostatic hypertrophy. Br J Pharmacol. 1996 Jul;118(6):1403-8. [Article]
- Sofowora GG, Dishy V, Landau R, Xie HG, Prasad HC, Byrne DW, Smiley RM, Kim RB, Wood AJ, Stein CM: Alpha 1A-adrenergic receptor polymorphism and vascular response. Clin Pharmacol Ther. 2004 Jun;75(6):539-45. [Article]
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Drug Relations
- Drug Relations
-
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00211 米idodrine approved yes agonist Details DB00246 Ziprasidone approved unknown antagonist Details DB00298 Dapiprazole approved yes antagonist Details DB00346 Alfuzosin approved, investigational yes antagonist Details DB00388 Phenylephrine approved yes agonist Details DB00457 Prazosin approved yes antagonist Details DB00590 Doxazosin approved yes antagonist Details DB00610 间羟胺 approved, investigational yes agonist Details DB00668 Epinephrine approved, vet_approved yes agonist Details DB00679 Thioridazine approved, withdrawn yes antagonist Details DB00696 Ergotamine approved yes partial agonist Details DB00699 Nicergoline approved, investigational yes antagonist Details DB00706 Tamsulosin approved, investigational yes antagonist Details DB00723 米ethoxamine approved, investigational yes agonist Details DB00797 Tolazoline approved, vet_approved yes antagonist Details DB00852 Pseudoephedrine approved yes agonist Details DB00875 Flupentixol approved, investigational, withdrawn unknown antagonist Details DB00925 Phenoxybenzamine approved yes antagonist Details DB00935 Oxymetazoline approved, investigational yes partial agonist Details DB01136 Carvedilol approved, investigational yes antagonistpotentiator Details DB01162 Terazosin approved yes antagonist Details DB00420 Promazine approved, vet_approved unknown antagonist Details DB00656 Trazodone approved, investigational no antagonist Details DB00777 丙酰马嗪 approved unknown antagonist Details DB00831 Trifluoperazine approved, investigational yes antagonist Details DB00865 Benzphetamine approved, illicit yes agonist Details DB01149 Nefazodone approved, withdrawn no antagonist Details DB01403 米ethotrimeprazine approved, investigational unknown antagonist Details DB01472 4-Methoxyamphetamine experimental, illicit yes agonist Details DB01579 Phendimetrazine approved, illicit yes agonist Details DB00368 Norepinephrine approved yes agonist Details DB04855 Dronedarone approved yes antagonist Details DB00751 Epinastine approved, investigational unknown unknown Details DB06144 Sertindole approved, investigational, withdrawn unknown Details DB05469 R450 investigational unknown Details DB05492 Epicept NP-1 investigational unknown Details DB06262 Droxidopa approved, investigational yes agonist Details DB06216 Asenapine approved unknown antagonist Details DB06229 Ocaperidone investigational unknown Details DB06694 Xylometazoline approved, investigational yes agonistpartial agonist Details DB01186 Pergolide approved, investigational, vet_approved, withdrawn unknown agonist Details DB01200 Bromocriptine approved, investigational, withdrawn unknown antagonistagonist Details DB00622 Nicardipine approved, investigational unknown antagonist Details DB01267 Paliperidone approved unknown antagonist Details DB01364 Ephedrine approved yes agonist Details DB00964 Apraclonidine approved yes agonist Details DB00363 Clozapine approved no antagonist Details DB01238 Aripiprazole approved, investigational no antagonist Details DB00334 Olanzapine approved, investigational unknown antagonist Details DB00450 Droperidol approved, vet_approved yes antagonist Details DB01295 贝凡洛尔 experimental unknown antagonist Details DB01624 Zuclopenthixol approved, investigational unknown antagonist Details DB00321 Amitriptyline approved no antagonistinhibitor Details DB01142 Doxepin approved, investigational unknown antagonist Details DB00458 Imipramine approved no antagonist Details DB00540 Nortriptyline approved no antagonist Details DB00543 Amoxapine approved unknown antagonist Details DB00726 Trimipramine approved unknown antagonist Details DB00692 Phentolamine approved yes antagonist Details DB00477 Chlorpromazine approved, investigational, vet_approved yes antagonist Details DB00449 Dipivefrin approved yes agonist Details DB01253 Ergometrine approved yes agonist Details DB01614 Acepromazine experimental, vet_approved unknown antagonist Details DB01622 Thioproperazine experimental yes antagonist Details DB06711 Naphazoline approved, investigational yes agonist Details DB06706 Isometheptene approved yes agonist Details DB06207 Silodosin approved yes antagonist Details DB04946 Iloperidone approved unknown antagonist Details DB00408 Loxapine approved unknown binder Details DB00575 Clonidine approved unknown agonist Details DB00800 Fenoldopam approved unknown inhibitor Details DB00248 Cabergoline approved unknown binder Details DB09202 Cirazoline experimental yes agonist Details DB08950 Indoramin approved, withdrawn unknown antagonist Details DB09239 Niguldipine experimental unknown antagonist Details DB00908 Quinidine approved, investigational unknown antagonist Details DB00661 Verapamil approved unknown antagonist Details DB00555 Lamotrigine approved, investigational unknown inhibitor Details DB11124 Racepinephrine approved yes agonist Details DB06153 Pizotifen approved unknown antagonist Details DB12278 Propiverine approved, investigational yes antagonist Details DB04948 Lofexidine approved, investigational no agonist Details DB14185 Aripiprazole lauroxil approved, investigational no antagonist Details DB00502 Haloperidol approved unknown Details DB00734 Risperidone approved, investigational unknown antagonist Details DB06016 Cariprazine approved, investigational unknown antagonist Details DB00598 Labetalol approved yes antagonist Details DB00934 米aprotiline approved, investigational no antagonist Details DB01224 Quetiapine approved unknown antagonist Details DB01151 Desipramine approved, investigational no antagonist Details DB00477 Chlorpromazine approved, investigational, vet_approved unknown inhibitor Details DB00370 米irtazapine approved unknown antagonist Details DB00543 Amoxapine approved unknown antagonist Details DB06148 米ianserin approved, investigational unknown antagonist Details DB06764 Tetryzoline approved yes agonist Details DB13025 Tiapride investigational yes antagonist Details DB08922 Perospirone experimental unknown antagonist Details DB09167 Dosulepin approved yes antagonist Details DB00841 Dobutamine approved yes agonist Details DB09203 Synephrine experimental unknown Details DB09194 Etoperidone withdrawn unknown antagonist Details DB09195 Lorpiprazole approved yes antagonist Details DB09204 Arotinolol investigational yes antagonist Details DB09286 Pipamperone investigational unknown antagonist Details DB00243 Ranolazine approved, investigational no antagonist Details DB00457 Prazosin approved unknown Details DB00697 Tizanidine approved, investigational unknown agonist Details DB00433 Prochlorperazine approved, vet_approved unknown antagonist Details DB00490 Buspirone approved, investigational unknown partial agonist Details DB00715 Paroxetine approved, investigational unknown binder Details DB01175 Escitalopram approved unknown inhibitor Details DB01136 Carvedilol approved, investigational yes inhibitor Details DB00346 Alfuzosin approved, investigational yes antagonist Details DB00320 Dihydroergotamine approved, investigational unknown agonist Details DB01365 米ephentermine approved yes agonist Details DB00182 Amphetamine approved, illicit, investigational unknown agonist Details DB09205 米oxisylyte approved, investigational yes antagonist Details DB09229 Aranidipine experimental unknown agonist Details DB11577 Indigotindisulfonic acid approved, investigational no agonist Details DB13345 Dihydroergocristine approved, experimental yes antagonistagonist Details DB01049 Ergoloid mesylate approved yes antagonistagonist Details DB11273 Dihydroergocornine approved yes antagonistagonist Details DB11278 DL-Methylephedrine approved yes agonist Details DB00268 Ropinirole approved, investigational unknown antagonist Details DB01069 Promethazine approved, investigational unknown antagonist Details DB01576 Dextroamphetamine approved, illicit unknown inhibitorinducer Details